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Mishra, M. N.
- An Investigation on Dynamic Alterations in Antioxidant Enzymes in Tumor Tissue and Blood of Oral Squamous Cell Carcinoma Patients
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Authors
Affiliations
1 Department of Oral and Maxillofacial Pathology, Dental College & Hospital, Azamgarh, U.P., IN
2 Department of Biochemistry, Dental College & Hospital, Azamgarh, U.P., IN
1 Department of Oral and Maxillofacial Pathology, Dental College & Hospital, Azamgarh, U.P., IN
2 Department of Biochemistry, Dental College & Hospital, Azamgarh, U.P., IN
Source
Indian Journal of Public Health Research & Development, Vol 3, No 1 (2012), Pagination: 79-82Abstract
Background
Oral squamous cell carcinoma is a devastating disease accounting for 50-70% of total cancer mortality in India. The disease is mediated by a diversity of endogenous and environmental stimuli. "Free radicals" are postulated to be involved in pathogenesis of oral squamous cell carcinoma. The antioxidant defence system of the body protects cell injury induced by these free radicals. Oxidative damages or alterations occur when there is imbalance, between free radicals production and cell's oxidant capacity. Such types of oxidative stress may lead to cytotoxicity, mutation and change in genetic expression resulting in carcinogenesis.
Objectives
To investigate the dynamic alterations of antioxidant level in tumor tissue and blood of oral squamous cell carcinoma patients.
Material and Method
Levels of antioxidants such as reduced glutathione (GSH) and ascorbic acid (AA) and the activities of Antioxidant enzymes superoxide dismutase (SOD), glutathione peroxides (GPx), glutathione reductase (GR), were estimated in the tumor tissue and blood of 40 oral squamous cell carcinoma (OSCC) patients and in 20 healthy subjects as control.
Results
Significantly, increased levels of GSH, GPx, GR and AA, and significantly decreased activity of SOD was observed in tumor tissue (p < 0.001) and in tumor-free tissue of oral sqamous cell carcinoma patients, as compared with healthy subjects. In contrast, decrease in antioxidants (GSH, GPx, GR and AA p < 0.001, SOD p < 0.05 respectively) was observed in the blood of oral squamous cell carcinoma patients, as compared with healthy subjects.
Keywords
Antioxidant Enzymes, Free Radicals, Oxidative Stress, Oral Squamous Cell Carcinoma (OSCC)
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- Mouth Mirrors Systemic Diseases
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Authors
Affiliations
1 Department of Oral & Maxillofacial Pathology, Dental College and Hospital, Chandesar, Azamgarh, U.P., IN
1 Department of Oral & Maxillofacial Pathology, Dental College and Hospital, Chandesar, Azamgarh, U.P., IN
Source
Indian Journal of Public Health Research & Development, Vol 3, No 1 (2012), Pagination: 83-86Abstract
The oral cavity is an important anatomical location with a role in many critical physiologic processes, such as mastication, digestion, respiration, and phonation. It is unique for the presence of exposed hard tissue surrounded by mucosa. The oral cavity might well be thought as window to the body because oral manifestations accompany a wide array of systemic diseases. In many instances, oral involvement precedes the appearance of other symptoms or lesions at other locations. These oral manifestations must be properly recognized if the patient is to receive appropriate diagnosis and referral for further treatment. This article is intended to highlight the lesions of oral mucosa, dentition, salivary glands, facial skeleton, extra-oral skin and other related structures that also involve some systemic diseases.Keywords
Oral Cavity, Oral Manifestations, Systemic DiseasesReferences
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